AcariaHealth is proud to partner with Pfizer, Inc. to offer an innovative new treatment option for individuals living with hemophilia A or B: HYMPAVZI™ (marstacimab-hncq), the first and only FDA-approved once-weekly subcutaneous anti-tissue factor pathway inhibitor (anti-TFPI) treatment available in a prefilledauto-injector pen.  

HYMPAVZI is approved for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adults and pediatric patients aged 12 years and older with hemophilia A (without factor VIII inhibitors) or hemophilia B (without factor IX inhibitors).

Understanding Hemophilia A and Hemophilia B

Hemophilia is a rare, inherited bleeding disorder where a person’s blood does not clot properly.

• Hemophilia A is caused by a deficiency or dysfunction of clotting factor VIII (FVIII).
• Hemophilia B results from a lack or defect of clotting factor IX (FIX).

These deficiencies can result in prolonged bleeding after injuries, surgeries, or even spontaneous bleeding into joints, muscles, and internal organs. Over time, this can lead to serious complications, including long-term joint damage.

Historically, management of hemophilia has required frequent intravenous infusions of clotting factors to prevent or control bleeds. This approach can be logistically burdensome and emotionally taxing for both patients and caregivers. 

A New Approach: Reducing Burden and Advancing Care

HYMPAVZI represents a meaningful advancement in the treatment of hemophilia A and B. Rather than replacing missing clotting factors, HYMPAVZI works by targeting and blocking tissue factor pathway inhibitor (TFPI), a naturally occurring protein that slows blood clotting. By inhibiting TFPI, HYMPAVZI increases the production of thrombin, a key enzyme that helps form blood clots.

This mechanism of action is expected to significantly reduce bleeding episodes—with the convenience of once-weekly subcutaneous injections via a pre-filled, auto-injector pen. Patients no longer need to rely on time-consuming IV infusions, improving treatment adherence and overall quality of life.

Support You Can Count On

At AcariaHealth, we go beyond simply dispensing medication. We’re your trusted specialty pharmacy partner, supporting patients with compassionate care and high-touch services tailored to their unique needs. We work in tandem with providers as an extension of their teams.

Our dedicated pharmacists and clinical team provide:

• Personalized support for onboarding and therapy initiation
• Timely delivery of medications to your home or preferred location
• Ongoing clinical check-ins and therapy guidance
• A responsive care team that offers peace of mind every step of the way

Whether you're starting HYMPAVZI or exploring treatment options, AcariaHealth is here to simplify your journey and help you live, with confidence in your care. Contact us today to speak with a member of our clinical team.

Learn More

Discover more about HYMPAVZI and explore helpful resources:

🔗 hympavzi.com – For patients and families

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